Who should not take Anafranil?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • pheochromocytoma
  • overactive thyroid gland
  • suicidal thoughts
  • serotonin syndrome
  • a type of disorder with high serotonin levels
  • heart attack within the last 30 days
  • seizures
  • a condition with high fevers and muscle contractions called malignant hyperthermia
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • neuroblastoma
  • manic-depression
  • closed angle glaucoma
  • an atrioventricular conduction defect in the heart
  • liver problems
  • an inability to completely empty the bladder
  • CYP2D6 poor metabolizer
  • chronic kidney disease stage 4 (severe)
  • alcohol use disorder
  • orthostatic hypotension
  • a form of low blood pressure


  • Tricyclic Antidepressants and Tricyclic Compounds

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.