Ulipristal/Rifamycins Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Rifamycins (rifabutin, rifampin, and rifapentine) may speed up how quickly your liver processes ulipristal. This effect may last for 2-3 weeks after you stop taking rifamycins.

What might happen:

Ulipristal may not be as effective if you are taking or have taken a rifamycin in the previous 3 weeks.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together, or have taken a rifamycin recently. Discuss your options with your healthcare provider.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Ellaone (ulipristal acetate) UK summary of product characteristics. HRA Pharma UK Ltd May 15, 2009.
  • 2.Ella (ulipristal acetate) US prescribing information. Afaxys Inc June, 2021.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.