Nifedipine/Selected CYP3A4 Inducers Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process nifedipine more quickly.
What might happen:
The beneficial effects of your nifedipine may decrease.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your nifedipine or change you to a different medicine while you are taking enzalutamide or rifampin and for a few weeks after you are done taking it.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Adalat (nifedipine) US prescribing information. Bayer Healthcare Pharmaceuticals Inc. August, 2016.
- 2.Holtbecker N, Fromm MF, Kroemer HK, Ohnhaus EE, Heidemann H. The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism. Drug Metab Dispos 1996 Oct;24(10):1121-3.
- 3.Ndanusa BU, Mustapha A, Abdu-Aguye I. The effect of single does of rifampicin on the pharmacokinetics of oral nifedipine. J Pharm Biomed Anal 1997 Jun;15(9-10):1571-5.
- 4.Yoshimoto H, Takahashi M, Saima S. Influence of rifampicin on antihypertensive effects of dihydropiridine calcium-channel blockers in four elderly patients. Nippon Ronen Igakkai Zasshi 1996 Sep;33(9):692-6.
- 5.Tada Y, Tsuda Y, Otsuka T, Nagasawa K, Kimura H, Kusaba T, Sakata T. Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension. Am J Med Sci 1992 Jan; 303(1):25-7.
- 6.Tsuchihashi K, Fukami K, Kishimoto H, Sumiyoshi T, Haze K, Saito M, Hiramori K. A case of variant angina exacerbated by administration of rifampicin. Heart Vessels 1987;3(4):214-7.
- 7.Xtandi (enzalutamide) US prescribing information. Astellas Pharma US, Inc. September, 2022.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.