Afatinib/P-glycoprotein (P-gp) Inducers; Phenobarbital Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may decrease how much afatinib is absorbed into your blood.
What might happen:
Your afatinib may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Make sure they know if you are taking, or have stopped taking apalutamide, carbamazepine, efavirenz, lorlatinib, phenobarbital, phenytoin, primidone, rifabutin, rifampin, rifapentine, or St. John's wort. Your doctor may want to adjust the afatinib dose.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Gilotrif (afatinib) prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. October, 2019.
- 2.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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- 4.King PK, Stump TA, Walkama AM, Ash BM, Bowling SM. Management of Phenobarbital and Apixaban Interaction in Recurrent Cardioembolic Stroke. Ann Pharmacother 2018 Jun;52(6):605-606.
- 5.Wen T, Liu YC, Yang HW, Liu HY, Liu XD, Wang GJ, Xie L. Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain. J Neurol Sci 2008 Jul 15; 270(1-2):99-106.
- 6.Yang HW, Liu HY, Liu X, Zhang DM, Liu YC, Liu XD, Wang GJ, Xie L. Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro. Neurosci Lett 2008 Apr 4;434(3):299-303.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.