Azole Antifungal Agents/Rifabutin Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifabutin may increase how quickly your body processes your antifungal medicine. Also, your antifungal medicine slow down how quickly your body processes rifabutin.
What might happen:
The anti-infective effects of your antifungal medicine may decrease. Your rifabutin may cause more side effects when taken with your antifungal medicine, including eye inflammation.
What you should do about this interaction:
If you notice any vision changes, or signs of your infection do not improve or worsen, contact your doctor immediately. It may be necessary to adjust the dose of your medicines or to change your medicines.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
- 1.Mycobutin (rifabutin) US prescribing information. Pfizer Inc. September, 2021.
- 2.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
- 3.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 4.Diflucan (fluconazole) US prescribing information. Pfizer Inc. January, 2023.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.