Dapsone/Rifamycins Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifabutin, rifampin, and rifapentine may speed up how quickly your body processes dapsone.
What might happen:
The levels of dapsone in your blood may be decreased, and your dapsone therapy may not work.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to consider changing one or both of the medicines or closely monitor how well each medicine is working.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Rifadin (rifampin) US prescribing information. Sanofi-Aventis U.S. LLC December, 2023.
- 2.Mycobutin (rifabutin) US prescribing information. Pfizer Inc. September, 2021.
- 3.Dapsone US prescribing information. Virtus Pharmaceuticals November, 2019.
- 4.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV. Department of Health and Human Services. Available at https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/Adul t_OI.pdf Accessed October 26, 2020..
- 5.Jorde UP, Horowitz HW, Wormser GP. Significance of drug interactions with rifampin in Pneumocystis carinii pneumonia prophylaxis. Arch Intern Med 1992 Nov;152(11):2348.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.