Felbamate/Valproic Acid Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process valproic acid more slowly.
What might happen:
The blood levels of valproic acid may increase and cause toxic effects.
What you should do about this interaction:
If you develop confusion, dizziness, or other unusual effects, contact your doctor. The dose of your medicines may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Felbatrol (felbamate) US prescribing information. MedPoint Pharmaceuticals Inc. August 27, 2012.
- 2.Wagner ML, Graves NM, Leppik IE, Remmel RP, Ward DL, Shumaker RC. The effect of felbamate on valproate disposition. Epilepsia 1991;32(3):15.
- 3.Hooper WD, Franklin ME, Glue P, Banfield CR, Radwanski E, McLaughlin DB, McIntyre ME, Dickinson RG, Eadie MJ. Effect of felbamate on valproic acid disposition in healthy volunteers: inhibition of beta-oxidation. Epilepsia 1996 Jan;37(1):91-7.
- 4.Delgado MR. Changes in valproic acid concentrations and dose/level ratios by felbamate coadministration in children. Ann Neurol 1994;36:538.
- 5.Wagner ML, Graves NM, Leppik IE, Remmel RP, Shumaker RC, Ward DL, Perhach JL. The effect of felbamate on valproic acid disposition. Clin Pharmacol Ther 1994 Nov;56(5):494-502.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.