Dexamethasone; Methylprednisolone/Aprepitant (Greater Than 40 mg); Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your anti-nausea medicine may slow down how quickly your liver processes dexamethasone and methylprednisolone.
What might happen:
Your blood levels of dexamethasone and methylprednisolone may increase and cause harmful effects.
What you should do about this interaction:
If you experience vomiting of blood, black or tarry stools, puffing of the face, swelling of the ankles or feet, unusual weight gain, prolonged sore throat or fever, muscle weakness, breathing difficulties or mood changes, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Emend (aprepitant) US prescribing information. Merck & Co., Inc. September, 2019.
- 2.Emend (fosaprepitant) US prescribing information. Merck Sharp & Dohme Corp. March, 2018.
- 3.Nakade S, Ohno T, Kitagawa J, Hashimoto Y, Katayama M, Awata H, Kodama Y, Miyata Y. Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 2008 Dec;63(1):75-83.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.