Avacopan/Lonafarnib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Avacopan and lonafarnib may both slow down how quickly your liver processes the other.
What might happen:
The amount of avacopan and lonafarnib in your blood may increase, which may cause more side effects than normal including nausea and vomiting, increased risk of infection, high blood pressure, and liver toxicity.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Ask your pharmacist what side effects to look for and report for the medicine you are taking.Call your healthcare provider right away if you have any unexplained symptoms such as yellowing of your skin or white part of your eyes, pain on the upper right side of your stomach area, feeling tired, dark or brown urine, bleeding or bruising more easily than normal, or loss of appetite. Notify your healthcare provider if you have fever or any symptoms of infection.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Tavneos (avacopan) US prescribing information. ChemoCentryx, Inc. October, 2021.
- 2.Zokinvy (lonafarnib) US prescribing information. Eiger BioPharmaceuticals, Inc. November, 2020.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.