Hormonal Contraceptives/Selected Strong & Moderate CYP3A4 Inducers Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may speed up how quickly your body processes your hormonal contraceptive.
What might happen:
Hormonal contraceptives (e.g. "the pill", patches, implants, some IUDs, and the ring) may not be effective while you are taking your other medicine, and you may become pregnant if you do not use other forms of birth control.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You should use a back-up form of birth control (e.g. condoms) or a non-hormonal form of birth control while taking your other medicine, and after stopping your other medicine for as long as instructed by your healthcare provider. If you have questions about your birth control, discuss them with your doctor or pharmacist.Emergency contraceptives may be less effective also. You may need a larger dose than normal. Discuss the dose and the need to confirm that you do not become pregnant with a pregnancy test with your healthcare professional.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Tibsovo (ivosidenib) US prescribing information. Agios Pharmaceuticals, Inc. August, 2021.
- 2.Le Corvaisier C, Capelle A, France M, Bourguignon L, Tod M, Goutelle S. Drug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction. Fundam Clin Pharmacol 2021 Apr;35(2):208-216.
- 3.Lysodren (mitotane) US prescribing information. E.R. Squibb & Sons, L.L.C. January, 2024.
- 4.Erleada (apalutamide) US prescribing information. Janssen Biotech, Inc. July, 2021.
- 5.Xtandi (enzalutamide) US prescribing information. Astellas Pharma US, Inc. September, 2022.
- 6.Medicines and Healthcare products Regulatory Agency. Levonorgestrel-containing emergency hormonal contraception: advice on interactions with hepatic enzyme inducers and contraceptive efficacy. available at: https://www.gov.uk/drug-safety-update/levonorgestrel-containing-emergency- hormonal-contraception-advice-on-interactions-with-hepatic-enzyme-inducers -and-contraceptive-efficacy September 15, 2016..
- 7.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 8.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.