Hormonal Contraceptives/Pegaspargase Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Pegaspargase may affect how your body processes your contraceptives.
What might happen:
The amount of contraceptives in your body may increase and cause more side effects than usual, including blood clots.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines. Your doctor may want to you to use a non-hormonal form of contraception while you are taking pegaspargase and for 3 months after you stop.If you develop a warm or hardened area in your legs, aching in the legs, problems bearing weight on your legs, chest pain, or shortness of breath, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Oncaspar (pegaspargase) Australian product information. Servier Laboratories (Aust.) Pty. Ltd. May, 2023.
- 2.Oncaspar (pegaspargase) UK Summary of Product Characteristics. Les Laboratoires Servier March, 2023.
- 3.Beavers CJ, Rodgers JE, Bagnola AJ, Beckie TM, Campia U, Di Palo KE, Okwuosa TM, Przespolewski ER, Dent S. Cardio-Oncology Drug Interactions: A Scientific Statement From the American Heart Association. Circulation 2022 Apr 12;145(15):e811-e838.
- 4.Oncaspar (pegaspargase) US prescribing information. Servier Pharmaceuticals LLC December, 2022.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.