Pemetrexed/Selected NSAIDs; Aspirin (Greater Than 325 mg) Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
NSAIDs (nonsteroidal antiinflammatory drugs) or aspirin may prevent your kidneys from removing pemetrexed from your body.
What might happen:
The amount of pemetrexed in your body may increase and cause more side effects than normally expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking any NSAIDs or aspirin. Depending upon your NSAID or aspirin dose, your doctor may want you to stop taking your NSAID or aspirin for a few days before and a few days after your pemetrexed treatment. Your doctor may want to change the NSAID that you are taking.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Alimta (pemetrexed for injection) US prescribing information. Eli Lilly and Company June, 2018.
- 2.Personal Communication: Alimta - Use with nsaids or aspirin. Eli Lilly and Company February 10, 2004.
- 3.Sweeney CJ, Takimoto CH, Latz JE, Baker SD, Murry DJ, Krull JH, Fife K, Battiato L, Cleverly A, Chaudhary AK, Chaudhuri T, Sandler A, Mita AC, Rowinsky EK. Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or Ibuprofen in patients with advanced cancer. Clin Cancer Res 2006 Jan 15; 12(2):536-42.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.