Pexidartinib/Vonoprazan Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your GI tract needs to be acidic for pexidartinib to dissolve and be absorbed. Proton pump inhibitors decrease the acidity in your GI tract.If pexidartinib is absorbed into your body, it can speed up how quickly your body processes your ulcer medicine. In addition, your ulcer medicine can slow down how quickly your body processes pexidartinib.

What might happen:

The amount of pexidartinib absorbed into your blood may be too low, and it may not work as well.If pexidartinib is absorbed, it may cause the amount of ulcer medicine in your blood to be too low and it also may not work as well. In addition, your ulcer medicine may cause the pexidartinib that is absorbed into your blood to accumulate and result in more side effects than expected. You may have an increased risk of developing serious liver problems. Signs of liver problems may include yellowing of the skin or eyes or abdominal pain.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change the dose of your pexidartinib. Let your doctor know right away if you have any signs of problems with your liver, such as abdominal pain, nausea/vomiting, yellowing of the eyes or skin, or dark urine.If you need to use an antacid while on pexidartinib, take the antacid at least 2 hours before or 2 hours after your pexidartinib.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Turalio (pexidartinib) US prescribing information. Daiichi Sankyo, Inc. November, 2023.
  • 2.Voquezna (vonoprazan-amoxicillin and vonoprazan-amoxicillin-clarithromycin) US prescribing information. Phathom Pharmaceuticals, Inc. November, 2023.
  • 3.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
  • 4.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.