Buspirone/Strong CYP3A4 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your other medicine may slow down how quickly your body processes buspirone.
What might happen:
The amount of buspirone in your blood may increase and cause more side effects than normal, such as lightheadedness, dizziness, weakness, or sleepiness.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your buspirone while you are taking your other medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Kivisto KT, Lamberg TS, Kantola T, Neuvonen PJ. Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole. Clin Pharmacol Ther 1997 Sep;62(3):348-54.
- 2.Buspar (buspirone hydrochloride) Australian prescribing information. Bristol-Myers Squibb Australia Pty Ltd. October 10, 2001.
- 3.Buspar (buspirone hydrochloride) UK summary of product characteristics. Bristol-Myers Squibb Pharmaceuticals Limited August 6, 2002.
- 4.BuSpar (buspirone hydrochloride) US prescribing information. Bristol Myers Squibb Company September, 2007.
- 5.Kivisto KT, Lamberg TS, Neuvonen PJ. Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone. Pharmacol Toxicol 1999 Feb;84(2):94-7.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.