Rilpivirine/Proton Pump Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rilpivirine needs some gastric acid to be absorbed. Proton pump inhibitors decrease the amount of acid in your stomach.
What might happen:
The amount of rilpivirine that is absorbed into your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change your proton pump inhibitor to another medicine. If your doctor instructs you to take a H2 antagonist (e.g. cimetidine, famotidine, nizatidine, ranitidine), take it at least 12 hours before or 4 hours after you take your rilpivirine. If your doctor instructs you to take an antacid (aluminum/magnesium hydroxide, calcium carbonate), take it at least 2 hours before or 4 hours after you take your rilpivirine. If you have any questions about how or when to take your medicine, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Edurant (rilpivirine) US prescribing information. Tibotec Pharmaceuticals January, 2021..
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.