Cariprazine/Strong CYP3A4 Inhibitors; Protease Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your other medicine may slow down how quickly your liver processes cariprazine.

What might happen:

The amount of cariprazine in your blood may increase and cause more side effects.

What you should do about this interaction:

Make sure your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together, especially if the medicines were prescribed by different doctors. Your doctor may want to lower the dose of your cariprazine while you are taking your other medicine. Let your doctor know if you notice an increase in side effects from your medicine, especially if you have restlessness/feeling like you have to move or increased anxiety; if you have muscle stiffness, spasms or tremors, or uncontrolled muscle movements.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Vraylar (cariprazine) US prescribing information. Forest Laboratories LLC December, 2022.
  • 2.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents Living with HIV. Department of Health and Human Services. Available at: nd-adolescent-arv/whats-new March 23, 2023.
  • 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
  • 4.Vraylar (cariprazine) Canadian Product Monograph. AbbVie Corporation March 6, 2024.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.