Cannabidiol-Tetrahydrocannabinol/Strong CYP3A4 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your other medicine may slow down how quickly your body processes cannabidiol (CBD) and tetrahydrocannabinol (THC).

What might happen:

The amount of CBD or THC in your blood may increase and cause more side effects than normal, including feeling sleepy, tired, dizzy, or euphoric.

What you should do about this interaction:

Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have unexplained nausea, vomiting, abdominal pain, yellowing of the skin or eyes, or very dark urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Sativex (delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)) Canadian prescribing information. GW Pharma Ltd. December 11, 2019.
  • 2.NanaBis (cannabidiol, tetrahydrocannabinol) Australian prescribing information. Medlab Clinical LTD. November 2022.
  • 3.Stott C, White L, Wright S, Wilbraham D, Guy G. A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers. Springerplus 2013 Dec; 2(1):236.
  • 4.Patsalos PN, Szaflarski JP, Gidal B, VanLandingham K, Critchley D, Morrison G. Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs. Epilepsia 2020 Sep 12.
  • 5.Epidiolex (cannabidiol) US prescribing information. Greenwich Biosciences, Inc. September, 2021.
  • 6.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.