Tolterodine (Greater Than 1 mg IR or Greater Than 2 mg ER)/Strong CYP3A4 Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medicine may prevent your body from processing tolterodine correctly.
What might happen:
The levels of tolterodine in your blood may increase. You may notice an increase in side effects from your tolterodine, such as blurred vision, dizziness, drowsiness, dry mouth, upset stomach, headache, dry eyes, or constipation.
What you should do about this interaction:
If you notice an increase in any side effects from your tolterodine, contact your healthcare professional (e.g. doctor or pharmacist). Your doctor may want to decrease the dose of your tolterodine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Detrol (tolterodine tartrate) US prescribing information. Pfizer Inc. August, 2012.
- 2.Detrol LA (tolterodine tartrate) US prescribing information. Pfizer Inc. July, 2018.
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- 4.American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2023 Jul;71(7):2052-2081.
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- 7.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 8.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.