Acalabrutinib/Vonoprazan-Clarithromycin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your cancer medicine needs some gastric acid to be absorbed. Proton pump inhibitors decrease the amount of acid in your stomach.Also, some medicines may slow down how quickly your liver processes acalabrutinib.

What might happen:

Your cancer medicine may not work as well if proton pump inhibitors decrease the amount that is absorbed into your blood.If your medicine is absorbed, the amount of acalabrutinib in your blood may increase and cause more side effects than expected. You may have an increase risk for infections, bleeding, or anemia.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to change the timing or dose of your acid reducing medicine to avoid an interaction with your cancer medicine. If you have any questions about how or when to take your medicine, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Calquence (acalabrutinib) US prescribing information. AstraZeneca Pharmaceuticals LP August, 2022.
  • 2.Voquezna (vonoprazan-amoxicillin and vonoprazan-amoxicillin-clarithromycin) US prescribing information. Phathom Pharmaceuticals, Inc. May, 2022.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.