Tadalafil (PAH)/Lenacapavir Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicines may slow down how quickly your liver processes tadalafil.

What might happen:

Your blood levels of tadalafil may increase and cause harmful effects.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. If you are taking tadalafil for pulmonary arterial hypertension (PAH), contact your doctor right away. Contact your doctor if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision. The dose of your tadalafil may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Cialis (tadalafil) US prescribing information. Eli Lilly and Company February, 2018.
  • 2.Sunlenca (lenacapavir) US prescribing information. Gilead Sciences, Inc. December, 2022.
  • 3.Sunlenca (lenacapavir) EMA Summary of Product Characteristics. Gilead Sciences Ireland UC August, 2022.
  • 4.Sunlenca (lenacapavir) Canadian Product Monograph. Gilead Sciences Canada, Inc. November, 2022.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.