Lenacapavir/Bosentan Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Bosentan may speed up how quickly your liver processes lenacapavir while lenacapavir may slow down how quickly your liver processes bosentan.
What might happen:
The overall effect of taking lenacapavir with bosentan is unknown. The amount of lenacapavir in your blood may decrease and lenacapavir may not work as well as expected. Alternatively, the amount of bosentan in your blood may increase and result in more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together, or have taken them within the last 9 months. Your doctor may want you to stop taking the medicines or monitor you more closely.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Sunlenca (lenacapavir) US prescribing information. Gilead Sciences, Inc. December, 2022.
- 2.Sunlenca (lenacapavir) Canadian Product Monograph. Gilead Sciences Canada, Inc. November, 2022.
- 3.Sunlenca (lenacapavir) EMA Summary of Product Characteristics. Gilead Sciences Ireland UC August, 2022.
- 4.Tracleer (bosentan) US prescribing information. Actelion Pharmaceuticals US, Inc. September 5, 2017.
- 5.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 6.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.