COVID-19 Vaccines/Orthopoxvirus Vaccines Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these vaccines may cause inflammation (or irritation) of your heart muscle (myocarditis) or heart lining (pericarditis).
What might happen:
You may have a higher risk of experiencing myocarditis or pericarditis.Myocarditis and pericarditis have occurred more frequently in adolescent and young adult males after the 2nd dose of COVID-19 vaccine and within a week of vaccination.Myopericarditis has occurred after smallpox vaccination with ACAM2000. It is unknown whether there is a risk with the smallpox-mpox vaccine (Jynneos).
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know if you have received either a COVID-19 vaccine or a smallpox-mpox vaccine in the past 4 weeks. Let your doctor know right away if you notice chest pain, shortness of breath, or a fast, fluttering, or pounding heartbeat (palpitations).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Centers for Disease Control and Prevention (CDC). Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States. Accessed at: https://www.cdc.gov/vaccines/covid-19/clinical-considerations/covid-19-vac cines-us.html Last updated: September 15, 2023.
- 2.Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, Campos-Outcalt D, Morgan RL, Damon I, Sanchez PJ, Bell BP. Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. MMWR Morb Mortal Wkly Rep 2022 Jun 3; 71(22):734-742.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.