Mycophenolate/Aluminum & Magnesium Antacids; Lanthanum; Sevelamer Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Medicines such as antacids that contain aluminum or magnesium, lanthanum, and sevelamer may decrease the amount of mycophenolate your body absorbs.

What might happen:

The levels of mycophenolate in your blood may decrease and the drug may not be as effective.

What you should do about this interaction:

You should not take any medicine containing magnesium and/or aluminum, lanthanum, or sevelamer at the same time you take your mycophenolate. You should separate taking the two medicines by several hours. Notify your healthcare professional (e.g. doctor or pharmacist) if you notice any change in your condition.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.CellCept (mycophenolate mofetil) US prescribing information. Roche Pharmaceuticals June, 2022.
  • 2.Myfortic (mycophenolate acid) US prescribing information. Novartis Pharmaceuticals Corporation September, 2013.
  • 3.Bullingham R, Shah J, Goldblum R, Schiff M. Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients. Br J Clin Pharmacol 1996 Jun;41(6):513-6.
  • 4.Pieper AK, Buhle F, Bauer S, Mai I, Budde K, Haffner D, Neumayer HH, Querfeld U. The effect of sevelamer on the pharmacokinetics of cyclosporin A and mycophenolate mofetil after renal transplantation. Nephrol Dial Transplant 2004 Oct;19(10):2630-3.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.