Iptacopan/Strong CYP2C8 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down how quickly your liver processes iptacopan.
What might happen:
The amount of iptacopan in your blood may increase and you may be at a higher risk for high cholesterol and serious infections when taking these two medicines together.
What you should do about this interaction:
Make sure healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicines while you are taking iptacopan.Seek medical care immediately if you experience fever with or without shivers or chills, chest pain and cough, breathlessness or fast breathing, high heart rate, headache with nausea or vomiting, back or neck stiffness, confusion, body aches with flu-like symptoms, clammy skin and/or eye sensitivity to light.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Fabhalta (iptacopan) US prescribing information. Novartis Pharmaceuticals Corporation December 2023.
- 2.Schmouder R, Shah B, Taylor A, Nidamarthy PK, Kulmatycki K. Assessment of drug interactions with Iptacopan. Poster Presented at ISN World Congress of Nephrology 2023 Bangkok// Thailand March 30-April 2//2023.
- 3.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 4.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.