Olmesartan/Colesevelam Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

If taken together your cholesterol medicine, colesevelam may bind to your blood pressure medicine, preventing your body from absorbing the blood pressure medicine.

What might happen:

A decrease in the beneficial effects of your blood pressure medicine may occur.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know you are taking these medicines together. Time your medicines so that you take your blood pressure medicine four hours before your cholesterol medicine, colesevelam. If you have any questions about how to take your medicines, ask your pharmacist. If you monitor your blood pressure, let your doctor know if your blood pressure increases.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Benicar (olmesartan medoxomil) US prescribing information. Daiichi Sankyo, Inc. October, 2019.
  • 2.Welchol (colesevelam hydrochloride) US prescribing information. Daiichi Sankyo, Inc. October, 2021.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.