Maralixibat; Odevixibat/Bile Acid Sequestrants Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Bile acid sequestrants can bind maralixibat and odevixibat in the gut and prevent their absorption.

What might happen:

Your maralixibat or odevixibat may not work as well, or may not work at all.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Taking maralixibat or odevixibat at least 4 hour before or 4 hours after the bile acid sequestrant may prevent this interaction. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Bylvay (odevixibat) US prescribing information. Albireo Pharma, Inc. July, 2021.
  • 2.Livmarli (Maralixibat) US prescribing information. Mirum Pharmaceuticals, Inc. September, 2021.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.