Roxadustat/Bile Acid Sequestrants; Sevelamer Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

If your cholesterol or phosphate binding medicine is taken too close to the time of your roxadustat dose, it may bind to roxadustat in your digestive tract, preventing your body from absorbing the roxadustat.

What might happen:

Your roxadustat may not work as well.

What you should do about this interaction:

It is important to time your medicines so that you take your roxadustat medicine at least one hour before or one hour after your cholesterol medicine or sevelamer.Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking both of these medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Evrenzo (roxadustat) UK summary of product characteristics. Atellas Pharma Europe B.V. November, 2021.
  • 2.Renagel (sevelamer hydrochloride) US prescribing information. Genzyme Corporation March 9, 2016.
  • 3.FDA (US Food and Drug Administration). Gastrointestinal Drug Advisory Committee (GIDAC) Meeting, FDA Background Document for NDA 207999 obeticholic acid. accessed at: /drugs/gastrointestinaldrugsadvisorycommittee/ucm494108.pdf March 15, 2016.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.