Sodium Phenylbutyrate-Taurursodiol/Aluminum-Based Antacids; Bile Acid Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

If your cholesterol medicine or antacid is taken too close to the time of your dose of sodium phenylbutyrate-taurursodiol, it may bind to the sodium phenylbutyrate-taurursodiol in your digestive tract, preventing your body from absorbing the sodium phenylbutyrate-taurursodiol.

What might happen:

A decrease in the beneficial effects of your sodium phenylbutyrate-taurursodiol may occur.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking both of these medicines. Your healthcare professional may need to change your antacid medicine or your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Relyvrio (sodium phenylbutyrate and taurursodiol) US prescribing information. Amylyx Pharmaceuticals, Inc. September, 2022.
  • 2.Albrioza (sodium phenylbutyrate and ursodoxicoltaurine) Canadian product monograph. Amylyx Pharmaceuticals Inc. June, 2022.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.