Nondepolarizing Muscle Relaxants/Piperacillin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are used together, piperacillin may increase the effects of your nondepolarizing muscle relaxant medicine.

What might happen:

The effects of your nondepolarizing muscle relaxant medicine may increase and last for a longer time, causing an increased chance for severe breathing problems.

What you should do about this interaction:

These medicines are used only during surgical procedures or with intensive monitoring in the hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to a hospital, make sure that all healthcare professionals are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicine, herbal medicines, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Zosyn (piperacillin and tazobactam) US prescribing information. Wyeth Pharmaceuticals July, 2021.
  • 2.Vecuronium bromide prescribing information. Pfizer Inc. February, 2011.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.