Atazanavir; Nelfinavir/Proton Pump Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Proton pump inhibitors increase the pH (decrease the acidity) of your stomach. Atazanavir needs an acidic environment to be absorbed by your body.Proton pump inhibitors may speed up how quickly your body processes nelfinavir.

What might happen:

The amount of atazanavir or nelfinavir in your blood may decrease and they may not work as well against your HIV infection.

What you should do about this interaction:

Contact your healthcare professional (e.g. doctor or pharmacist) right away about using these medicines together. Your doctor may want to check the amount of atazanavir or nelfinavir in your blood, as well as your viral load. Your doctor may want to change your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
  • 2.Reyataz (atazanavir sulfate) Australian product information. Bristol-Myers Squibb Pharmaceuticals October 25, 2023.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.