Selpercatinib/Proton Pump Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The pH of your GI tract needs to be acidic for selpercatinib to dissolve and be absorbed. Proton pump inhibitors change the pH (acidity) in your GI tract.

What might happen:

The amount of selpercatinib in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine.If you need to take a proton pump inhibitor with selpercatinib, take selpercatinib with food.If your doctor changes the proton pump inhibitor to an H2 blocker, take selpercatinib at least 2 hours before or 10 hours after the H2 blocker.If your doctor changes the proton pump inhibitor to an antacid, take selpercatinib at least 2 hours before or 2 hours after the antacid.If you have questions about how to schedule your medicines, ask your pharmacist.

  • 1.Retevmo (selpercatinib) US prescribing information. Eli Lilly April, 2024..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.