Methylphenidate XR-ODT/H2 Antagonists;Proton Pump Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Proton pump inhibitors and H2 blockers may cause your methylphenidate to dissolve in your stomach more quickly and result in more methylphenidate being absorbed into your blood than intended.

What might happen:

Your methylphenidate may not be as effective, or its effect may not last for as long. You may experience more side effects than expected, such as increased blood pressure, increased heart rate, irritability, anxiety, tremor, dizziness, blurred vision, nausea, vomiting, and abdominal pain.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to change your medicine to avoid an interaction with methylphenidate.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.FDA Center for Drug Evaluation and Research (CDER). CDER Application number: 205489 Cotempla XR-ODT (methylphenidate) Clinical Pharmacology and Biopharmaceutics Review. available at: nPharmR.pdf December, 2016.
  • 2.Cotempla XR-ODT (methylphenidate extended-release orally disintegrating tablets) US prescribing information. Neo Therapeutics, Inc. July, 2021.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.