Perphenazine-Amitriptyline Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • A Feeling Of Restlessness With Inability To Sit Still
  • Blurred Vision
  • Extrapyramidal Disease, A Type Of Movement Disorder
  • Fainting
  • Low Blood Pressure
  • Tardive Dyskinesia, A Disorder Characterized By Involuntary Movements Of The Face, Mouth And Tongue

If experienced, these tend to have a Less Severe expression

  • Constipation
  • Decreased Sweating
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Excessive Saliva Production
  • Headache
  • Increased Hunger
  • Inducing Of A Relaxed Easy State
  • Orthostatic Hypotension, A Form Of Low Blood Pressure
  • Poisoning Caused By Anticholinergic Medication
  • Stuffy Nose
  • Weight Gain

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • Abnormal Heart Rhythm
  • Abnormal Muscle Movements
  • An Inability To Completely Empty The Bladder
  • Contact Dermatitis, A Type Of Skin Rash That Occurs From Contact With An Offending Substance
  • Difficult Or Painful Urination
  • Increased Sensitivity Of The Skin To The Sun
  • Low Blood Pressure
  • Pigmentary Retinopathy
  • Slow Heartbeat

If experienced, these tend to have a Less Severe expression

  • A High Prolactin Level
  • A Type Of Abnormal Movement Disorder Called Dyskinesia
  • Abnormal Sexual Function
  • Abnormal Sexual Function
  • Absence Of Menstrual Periods
  • Altered Interest In Having Sexual Intercourse
  • An Abnormal Increase In Muscle Tone
  • Anxious Feelings
  • Blurred Vision
  • Breast Fullness Due To Milk Production
  • Breast Pain
  • Breastmilk Production Not Associated With Childbirth Or Nursing
  • Confusion
  • Constipation
  • Diarrhea
  • Difficulty Concentrating
  • Difficulty Sleeping
  • Excessive Sweating
  • Heartburn
  • High Blood Sugar
  • Irregular Periods
  • Low Energy
  • Muscle Tremors
  • Nervousness
  • Over Excitement
  • Poisoning Caused By Anticholinergic Medication
  • Taste Impairment
  • The Inability To Have An Erection
  • The Inability To Have An Erection
  • Vomiting
  • Weight Gain

RARE side effects


If experienced, these tend to have a Severe expression

  • A Blockage Of The Bile Duct That Resulting In High Bilirubin Levels
  • A Change In Vision
  • A Condition With Symptoms That Resemble Lupus
  • A Disorder Of The Retina Of The Eye
  • A Disorder With Excess Antidiuretic Hormone Called Syndrome Of Inappropriate Antidiuretic Hormone
  • A Heart Attack
  • A Stroke
  • A Type Of Allergic Reaction Called Angioedema
  • A Type Of Blood Disorder Where The Red Blood Cells Burst Called Hemolytic Anemia
  • A Type Of Movement Disorder Called Parkinsonism
  • A Type Of Slowed Heart Rhythm Disorder Called Heart Block
  • Abnormal Heart Electrical Signals
  • Abnormal Liver Function Tests
  • Accidental Falls
  • Decreased Blood Platelets
  • Extrapyramidal Disease, A Type Of Movement Disorder
  • Fast Heartbeat
  • Hallucinations
  • Heat Stroke
  • Increased Eosinophils In The Blood
  • Increased Pressure In The Eye
  • Increased Sensitivity Of The Skin To The Sun
  • Inflammation Of The Liver Called Hepatitis
  • Large Purple Or Brown Skin Blotches
  • Low Body Temperature
  • Low Levels Of A Type Of White Blood Cell Called Neutrophils
  • Low Levels Of White Blood Cells
  • Low Platelet Count And Bleeding From Immune Response
  • Melanosis, A Condition Where Increased Melanin Results In Hyperpigmentation
  • Mental Problems From Taking The Drug
  • Neuroleptic Malignant Syndrome, A Reaction Characterized By Fever, Muscle Rigidity And Confusion
  • Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis
  • Priapism, A Prolonged Erection Of The Penis
  • Prolonged QT Interval On EKG
  • Rapid Ventricular Heartbeat
  • Secondary Angle-Closure Glaucoma, A Type Of Eye Disorder
  • Seizures
  • Serotonin Syndrome, A Type Of Disorder With High Serotonin Levels
  • Sinus Tachycardia, A Type Of Fast Heart Rate
  • Skin Rash With Sloughing
  • Slurred Speech
  • Suicidal Thoughts
  • Swelling Of The Tongue
  • Tardive Dyskinesia, A Disorder Characterized By Involuntary Movements Of The Face, Mouth And Tongue
  • Torsades De Pointes, A Type Of Abnormal Heart Rhythm
  • Ventricular Arrhythmias, A Type Of Abnormal Heart Rhythm
  • Ventricular Fibrillation, A Heart Rhythm Disorder
  • Very Low Levels Of Granulocytes, A Type Of White Blood Cell

If experienced, these tend to have a Less Severe expression

  • A Discolored Tongue
  • A Feeling Of Pins And Needles On Skin
  • A Feeling Of Restlessness With Inability To Sit Still
  • A Form Of Mania That Has A Lower Severity Of Symptoms
  • A Painful Condition That Affects The Nerves In The Legs And Arms Called Peripheral Neuropathy
  • A Skin Rash
  • A Type Of Speech Disorder Called Dysarthria
  • Aggressive Behavior
  • Agitation
  • An Inability To Control Impulsive Behavior
  • Anxious Feelings
  • Breastmilk Production Not Associated With Childbirth Or Nursing
  • Clouding Of The Lens Of The Eye Called Cataracts
  • Decreased Appetite
  • Delusions
  • Dilated Pupils
  • Disturbance In The Ability Of The Eye To Focus
  • Enlarged Breasts
  • Fainting
  • Feelings Of Hostility
  • Fever
  • Fluid Retention In The Legs, Feet, Arms Or Hands
  • Hair Loss
  • Heart Throbbing Or Pounding
  • High Blood Pressure
  • High Blood Sugar
  • Hives
  • Hyperactive Behavior
  • Inflammation Of The Parotid Gland
  • Irritability
  • Itching
  • Loss Of Muscle Coordination
  • Low Blood Sugar
  • Manic Behavior
  • Nausea
  • Nightmares
  • Puffy Face From Water Retention
  • Ringing In The Ears
  • Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth
  • Swelling Of The Testicles
  • Visual Sensitivity To Light
  • Weight Loss

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.