Zoloft Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Less Severe expression

  • Abnormal Sexual Function
  • Altered Interest In Having Sexual Intercourse
  • Decreased Appetite
  • Diarrhea
  • Difficulty Sleeping
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Excessive Sweating
  • Gas
  • Headache
  • Indigestion
  • Intense Abdominal Pain
  • Low Energy
  • Muscle Tremors
  • Nausea
  • Problems With Ejaculation
  • The Inability To Have An Erection
  • Weight Loss

INFREQUENT side effects


If experienced, these tend to have a Less Severe expression

  • A Change In Vision
  • A Stuffy And Runny Nose
  • Acne
  • Agitation
  • An Abnormal Increase In Muscle Tone
  • Backache
  • Chest Pain
  • Constipation
  • Difficulty Concentrating
  • Hair Loss
  • Heart Throbbing Or Pounding
  • Increased Hunger
  • Irritability
  • Muscle Pain
  • Pain
  • Vomiting
  • Weight Gain

RARE side effects


If experienced, these tend to have a Severe expression

  • A Condition With Muscle Tissue Breakdown Called Rhabdomyolysis
  • A Condition With Symptoms That Resemble Lupus
  • A Disorder With Excess Antidiuretic Hormone Called Syndrome Of Inappropriate Antidiuretic Hormone
  • A Feeling Of Restlessness With Inability To Sit Still
  • A Serum Sickness Reaction
  • A Significant Type Of Allergic Reaction Called Anaphylaxis
  • A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
  • A Type Of Allergic Reaction Called Angioedema
  • A Yellowing Of The Eyes Or Skin From Buildup Of Bilirubin Called Jaundice
  • Abnormal Liver Function Tests
  • Acute Kidney Failure
  • Atrioventricular Block, A Type Of Slow Heart Rhythm Disorder
  • Bleeding
  • Bleeding Of The Stomach Or Intestines
  • Clouding Of The Lens Of The Eye Called Cataracts
  • Damage To The Liver And Inflammation
  • Decreased Blood Platelets
  • Diabetes
  • Extrapyramidal Disease, A Type Of Movement Disorder
  • High Blood Pressure
  • Liver Failure
  • Low Amount Of Sodium In The Blood
  • Low Blood Counts Due To Bone Marrow Failure
  • Manic Behavior
  • Microscopic Colitis
  • Neuroleptic Malignant Syndrome, A Reaction Characterized By Fever, Muscle Rigidity And Confusion
  • Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis
  • Pancreatitis
  • Pneumonia With High Amount Of Eosinophil White Blood Cells
  • Prolonged QT Interval On EKG
  • Rapid Ventricular Heartbeat
  • Secondary Angle-Closure Glaucoma, A Type Of Eye Disorder
  • Seizures
  • Serotonin Syndrome, A Type Of Disorder With High Serotonin Levels
  • Slow Heartbeat
  • Spasms Of Blood Vessels That Supply The Brain
  • Sudden Blindness And Pain Upon Moving The Eye
  • Suicidal Thoughts
  • Torsades De Pointes, A Type Of Abnormal Heart Rhythm
  • Very Low Levels Of Granulocytes, A Type Of White Blood Cell

If experienced, these tend to have a Less Severe expression

  • A Condition With Low Thyroid Hormone Levels
  • A Form Of Mania That Has A Lower Severity Of Symptoms
  • A High Prolactin Level
  • A Problem With Menstrual Periods
  • A Skin Rash
  • A Type Of Bumpy Skin Rash Called A Maculopapular Rash
  • Accidental Falls
  • Anxious Feelings
  • Bleeding Not Related To Menstrual Period
  • Bloody Urine
  • Blurred Vision
  • Breast Pain
  • Breastmilk Production Not Associated With Childbirth Or Nursing
  • Bruising Under The Skin
  • Difficulty Swallowing
  • Dilated Pupils
  • Enlarged Breasts
  • Excessive Thirst
  • Fainting
  • Fast Heartbeat
  • Feelings Of Hostility
  • Fever
  • Grinding Of The Teeth
  • High Blood Sugar
  • Hives
  • Hyperactive Behavior
  • Increased Sensitivity Of The Skin To The Sun
  • Inflammation Of The Blood Vessels
  • Inflammation Of The Skin Due To An Allergy
  • Involuntary Leakage Of Urine
  • Itching
  • Joint Pain
  • Large Purple Or Brown Skin Blotches
  • Lockjaw
  • Loss Of Muscle Coordination
  • Muscle Spasm
  • Nervousness
  • Nightmares
  • No Sense Of Smell
  • Nosebleed
  • Numbness
  • Orgasm Problems
  • Orthostatic Hypotension, A Form Of Low Blood Pressure
  • Poisoning Caused By Anticholinergic Medication
  • Priapism, A Prolonged Erection Of The Penis
  • Pulmonary Hypertension
  • Ringing In The Ears
  • Sensation Of Spinning Or Whirling
  • Skin Discoloration
  • Small Reddish-Purplish Pin-Point Sized Spots On Skin
  • Tooth Decay
  • Visible Water Retention
  • Widening Of Blood Vessels
  • Yawning

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.