Who should not take Coumadin?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • operation on the spine
  • cancer or malignancy
  • polycythemia vera
  • eye surgery
  • caloric undernutrition
  • low vitamin K levels
  • anemia
  • increased risk of bleeding due to clotting disorder
  • an increased risk of bleeding
  • decreased platelets due to the medication heparin
  • patient with catheter in the vascular system
  • significant uncontrolled high blood pressure
  • bacterial infection of heart valve
  • inflammation of the covering of the heart or pericardium
  • fluid in the covering of the heart or pericardium
  • a hemorrhage in the brain
  • balloon-like swelling of an artery of the brain
  • bulge and tear of the aorta blood vessel wall
  • a cholesterol embolism
  • bleeding
  • stomach or intestinal ulcer
  • severe liver disease
  • blockage of a bile duct
  • bleeding of the stomach or intestines
  • bowel movements containing much fat
  • decreased kidney function
  • bleeding from the genitourinary system
  • possibility of having a miscarriage
  • recent operation
  • fever
  • bleeding from the respiratory tract
  • excessive diarrhea
  • abnormal liver function tests
  • major traumatic injury
  • pregnancy
  • gangrene
  • tropical sprue
  • protein C deficiency disease
  • bleeding risk associated with vitamin K epoxide reductase (warfarin-sensitive) gene
  • CYP2C9 poor metabolizer
  • procedure to place indwelling epidural catheter
  • calciphylaxis
  • neuraxial anesthesia
  • local anesthesia injected in the epidural space or subarachnoid space
  • deep peripheral nerve block
  • deep plexus block
  • cerebral amyloid angiopathy


  • Coumarin Analogues

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.