Selected Anticoagulants (Vit K antagonists)/Chloral Hydrate; Triclofos Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process your blood-thinning medicine properly.

What might happen:

You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to check your bleeding times more often. The dose of your blood-thinner may need adjusting. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
  • 1.Cucinell SA, Odessky L, Weiss M, Dayton PG. The effect of chloral hydrate on bishydroxycoumarin metabolism; a fatal outcome. JAMA 1966 Aug 1; 197(5):366-8.
  • 2.MacDonald MG, Robinson DS, Sylwester D, Jaffe JJ. The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responese in man. Clin Pharmacol Ther 1969 Jan-Feb;10(1):80-4.
  • 3.Udall JA. Drug interference with warfarin therapy. Clin Med 1970 Aug; 77:20-5.
  • 4.Sellers EM, Koch-Weser J. Potentiation of warfarin-induced hypoprothrombinemia by chloral hydrate. N Engl J Med 1970 Oct 15; 283(16):827-31.
  • 5.Koch-Weser J, Sellers EM, Udall JA, Griner PF, Rickles FR. Chloral hydrate and warfarin therapy. Ann Intern Med 1971 Jul;75(1):141-2.
  • 6.Griner PF, Raisz LG, Rickles FR, Wiesner PJ, Odoroff CL. Chloral hydrate and warfarin interaction: clinical significance. Ann Intern Med 1971 Apr; 74(4):540-3.
  • 7.Breckenridge A, Orme ML, Thorgeirsson S, Davies DS, Brooks RV. Drug interactions with warfarin: studies with dichloralphenazone, chloral hydrate and phenazone (antipyrine). Clin Sci 1971 Apr;40(4):351-64.
  • 8.Sellers EM, Koch-Weser J. Kinetics and clinical importance of displacement of warfarin from albumin by acidic drugs. Ann N Y Acad Sci 1971 Jul 6; 179:213-25.
  • 9.Sellers EM, Lang M, Koch-Weser J, Colman RW. Enhancement of warfarin-induced hypoprothrombinemia by triclofos. Clin Pharmacol Ther 1972 Nov-Dec;13(6):911-5.
  • 10.Orme M, Breckenridge A, Brooks RV. Interactions of benzodiazepines with warfarin. Br Med J 1972 Sep 9;3(827):611-4.
  • 11.Anonymous. Chloral hydrate and oral anticoagulants. Lancet 1972 Mar 4; 1(7749):524.
  • 12.Anonymous. Interaction between chloral hydrate and warfarin. A report from the Boston Collaborative Drug Surveillance Program, Boston Universtiy Medical Center. N Engl J Med 1972 Jan 13;286(2):53-5.
  • 13.Beliles RP, Foster GV Jr. Interaction of bishydroxycoumarin with chloral hydrate and trichloroethyl phosphate. Toxicol Appl Pharmacol 1974 Feb; 27(2):225-9.
  • 14.Udall JA. Warfarin-chloral hydrate interaction. Pharmacological activity and clinical significance. Ann Intern Med 1974 Sep;81(3):341-4.
  • 15.Udall JA. Clinical implications of warfarin interactions with five sedatives. Am J Cardiol 1975 Jan;35(1):67-71.
Full Drug Information

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.