Glutethimide/Selected Anticoagulants (Vitamin K antagonists) Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process your blood-thinning medicine more quickly.
What might happen:
The effects of your blood-thinner may decrease and increase your risk for blood clots. If glutethimide is stopped, there is an increased chance for bleeding.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. It may be necessary to check your bleeding times more often. Your dose of blood-thinner may need to be adjusted, especially if your doctor stops your glutethimide. If you experience bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Udall JA. Clinical implications of warfarin interactions with five sedatives. Am J Cardiol 1975 Jan;35(1):67-71..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.