Selected Anticoagulants (Vitamin K antagonists)/Sitaxsentan Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Sitaxsentan may slow down how quickly your liver processes your anticoagulant.
What might happen:
You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check your bleeding times more often and your doctor may need to change the dose of your medicine. Let your doctor know right away if you have any symptoms of bleeding.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Gehshan A. Dear Canadian Healthcare Professional letter: Subject: Saftey information regarding Thelin (sitaxsentan sodium) and the ocurrence of liver toxicity, risks to the fetus, and important drug-drug interactions. Encysive Pharmaceuticals July 9, 2007.
- 2.Thelin (sitaxentan sodium) UK summary of product characteristics. Encysive (UK) Limited August 10, 2006.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.