Warfarin/Noscapine; Oxolamine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Noscapine may slow down how quickly your liver processes warfarin. How oxolamine affects warfarin is not known.
What might happen:
You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your warfarin while you are taking noscapine or oxolamine. If your doctor prescribes these medicines together, you may need to have your bleeding times checked more often. If you have any signs of bleeding, such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Ohlsson S, Holm L, Myrberg O, Sundstrom A, Yue QY. Noscapine may increase the effect of warfarin. Br J Clin Pharmacol 2008 Feb;65(2):277-8.
- 2.Scordo MG, Melhus H, Stjernberg E, Edvardsson AM, Wadelius M. Warfarin-noscapine interaction: a series of four case reports. Ann Pharmacother 2008 Mar;42(3):448-50.
- 3.Min KA, Zhu X, Oh JM, Shin WG. Effect of oxolamine on anticoagulant effect of warfarin. Am J Health Syst Pharm 2006 Jan 15;63(2):153-6.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.