Coumarin Anticoagulants/Dabrafenib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Dabrafenib may speed up how your body processes your blood thinner.
What might happen:
The effects of your blood thinner may decrease, which can increase your risk of a blood clot.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to have your INR or PT tests checked more often, especially when you first start taking dabrafenib or if your medicine dose changes.Once you are stabilized on this combination, it is important to keep taking both medicines as prescribed. For example, if you stop dabrafenib the amount of blood thinner (e.g. warfarin) in your system will gradually increase and could increase your risk for bleeding. It is important to notify your blood thinner health care provider of any change in the type or dose of dabrafenib.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Tafinlar (dabrafenib) US prescribing information. Novartis Pharmaceuticals Corporation May, 2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.