Icosapent Ethyl/Anticoagulant;Antiplatelet;Thrombolytic Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Anticoagulant (e.g. warfarin), antiplatelet (e.g. aspirin, clopidogrel) or thrombolytic medicines decrease your body's ability to make clots. When combined with icosapent ethyl, you may have increased bleeding or bruising.
What might happen:
If you take a medicine that decreases the ability of your blood to clot, you could have bleeding or bruising.
What you should do about this interaction:
Before receiving icosapent ethyl, make sure to inform your doctor and healthcare professionals of all the medicines you are taking, especially if: you are taking any prescription or nonprescription for pain, inflammation or fever; if you are taking any medicines that can affect blood clotting (e.g. aspirin, clopidogrel, warfarin and others) because many of these medicines can affect blood clotting. Your doctor will want to stop medicines which can decrease blood clotting for 7 days before receiving icosapent ethyl and for one or more days after treatment.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Vascepa (icosapent ethyl) US prescribing information. Amarin Pharms December, 2019.
- 2.Jalili M, Dehpour AR. Extremely prolonged INR associated with warfarin in combination with both trazodone and omega-3 fatty acids. Arch Med Res 2007 Nov;38(8):901-4.
- 3.McClaskey EM, Michalets EL. Subdural hematoma after a fall in an elderly patient taking high-dose omega-3 fatty acids with warfarin and aspirin: case report and review of the literature. Pharmacotherapy 2007 Jan; 27(1):152-60.
- 4.Buckley MS, Goff AD, Knapp WE. Fish oil interaction with warfarin. Ann Pharmacother 2004 Jan;38(1):50-2.
- 5.Smith P, Arnesen H, Opstad T, Dahl KH, Eritsland J. Influence of highly concentrated n-3 fatty acids on serum lipids and hemostatic variables in survivors of myocardial infarction receiving either oral anticoagulants or matching placebo. Thromb Res 1989 Mar 1;53(5):467-74.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.