Selected Anticoagulants (Vitamin K antagonists)/Carbamazepine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known. Carbamazepine may interfere with the way your body processes your blood thinner.
What might happen:
The beneficial effects of your blood thinner may decrease. Your chance of forming a blood clot may increase.
What you should do about this interaction:
This interaction is most likely to occur when starting, stopping, or changing the dose of your carbamazepine. Your doctor may want to check your blood tests more often during those times. It may be necessary to adjust the dose of your blood thinner.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. If your doctor prescribes these two medicines together, you may need to check your bleeding times more often. Do not stop, start, or change the dosage of any medicine before checking with them first.
- 1.Coumadin (warfarin sodium) US prescribing information. Bristol-Myers Squibb Company September, 2016.
- 2.Clark NP, Hoang K, Delate T, Horn JR, Witt DM. Warfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing Anticonvulsants. Clin Appl Thromb Hemost 2018 Jan;24(1):172-178.
- 3.Hansen JM, Siersboek-Nielsen K, Skovsted L. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin Pharmacol Ther 1971 May-Jun;12(3):539-43.
- 4.Ross JR, Beeley L. Interaction between carbamazepine and warfarin. Br Med J 1980 Jun 14;280(6229):1415-6.
- 5.Kendall AG, Boivin M. Warfarin-carbamazepine interaction. Ann Intern Med 1981 Feb;94(2):280.
- 6.Massey EW. Effect of carbamazepine on Coumadin metabolism. Ann Neurol 1983 Jun;13(6):691-2.
- 7.Denbow CE, Fraser HS. Clinically significant hemorrhage due to warfarin-carbamazepine interaction. South Med J 1990 Aug;83(8):981.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.