Rivoceranib/Fosphenytoin; Phenytoin Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Phenytoin may speed up how quickly your liver processes rivoceranib. Also, rivoceranib may slow down how quickly your liver processes phenytoin.
What might happen:
Your blood levels of rivoceranib may decrease and it may not work as well.Also, the amount of phenytoin in your blood may increase and cause toxic effects, such as nausea, vomiting, confusion, dizziness, changes in vision, loss of coordination, or drowsiness.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together or if you stop taking these medicines. Your doctor may need to change the dosage of your phenytoin or check the amount of phenytoin in your blood more frequently when you start or stop taking rivoceranib. Let your healthcare professional know if you have any symptoms of phenytoin toxicity (nausea, vomiting, confusion, dizziness, changes in vision, loss of coordination, or drowsiness).Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Aitan (rivoceranib (apatinib)) Hong Kong prescribing information. Jiangsu Hengrui Pharmaceutical Co., Ltd. December, 2014.
- 2.Dilantin (phenytoin sodium) US prescribing information. Pfizer, Inc. March, 2022.
- 3.Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF. Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors. Drug Des Devel Ther 2020;14:1963-1970.
- 4.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 5.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.