Fosphenytoin; Phenytoin/Azapropazone Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process your seizure medicine properly.
What might happen:
The blood levels of your seizure medicine may increase and cause toxic effects. You may experience slurred speech, increased confusion, nausea, unsteadiness walking, weakness, fatigue, or dizziness.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Rheumox (azapropazone) UK summary of product characteristics. Wyeth Laboratories 1997.
- 2.Dilantin (phenytoin sodium) US prescribing information. Pfizer, Inc. March, 2022.
- 3.Geaney DP, Carver JG, Davies CL, Aronson JK. Pharmacokinetic investigation of the interaction of azapropazone with phenytoin. Br J Clin Pharmacol 1983 Jun;15(6):727-34.
- 4.Geaney DP, Carver JG, Aronson JK, Warlow CP. Interaction of azapropazone with phenytoin. Br Med J (Clin Res Ed) 1982 May 8;284(6326):1373.
- 5.Roberts CJ, Daneshmend TK, Macfarlane D, Dieppe PA. Anticonvulsant intoxication precipitated by azapropazone. Postgrad Med J 1981 Mar; 57(665):191-2.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.