Heparin/Coagulation Factor Xa, Inactivated (Andexanet) Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Inactivated coagulation factor Xa may block the action of heparin.
What might happen:
Heparin may not work as expected and result in blood clots.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you have received inactivated coagulation factor Xa. Your doctor may choose to use a different medicine or monitor you more closely.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) US prescribing information. Portola Pharmaceuticals September, 2020.
- 2.Goldmann U. Dear Healthcare Professional letter: Ondexxya (andexanet alfa): Avoid use of andexanet prior to heparinization. Portola Netherlands, B.V. November 4, 2020.
- 3.Eche IM, Elsamadisi P, Wex N, Wyers MC, Brat GA, Cunningham K, Bauer KA. Intraoperative Unfractionated Heparin Unresponsiveness during Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm following Administration of Andexanet Alfa for the Reversal of Rivaroxaban. Pharmacotherapy 2019 Aug;39(8):861-865.
- 4.Watson CJ, Zettervall SL, Hall MM, Ganetsky M. Difficult Intraoperative Heparinization Following Andexanet Alfa Administration. Clin Pract Cases Emerg Med 2019 Nov;3(4):390-394.
- 5.Apostel HJCL, Winckers K, Bidar E, Schreiber JU. Successful Antithrombin Administration in Andexanet Alfa-Associated Heparin Resistance. J Cardiothorac Vasc Anesth 2020 Oct 24.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.