Buspirone/Nefazodone Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nefazodone may slow down how quickly your body processes your buspirone. If you are taking a higher dose of buspirone, buspirone may slow down how quickly your liver processes nefazodone.
What might happen:
The amount of nefazodone and buspirone in your blood may increase. The amount of buspirone in your blood will probably increase more than the amount of nefazodone in your blood. You may notice more side effects from your buspirone, such as lightheadedness, dizziness, weakness, or sleepiness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If you are experiencing side effects from your medicines, your doctor may want to change the dose of your medicine. If your doctor adds buspirone to your nefazodone, your doctor may start your buspirone at a lower dosage.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
- 2.BuSpar (buspirone hydrochloride) US prescribing information. Bristol Myers Squibb Company September, 2007.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.