Selected Anticoagulants (Vit K antagonists)/Selected Macrolide Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process the blood thinner more slowly.

What might happen:

You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Contact your doctor as soon as possible if you are taking these two medicines.You should watch for any unusual bleeding or bruising. Your bleeding times may need to be monitored and the dose of your blood thinner adjusted, or you may need to be switched to a different antibiotic.You should maintain good nutrition while on these medicines. This drug interaction may be more likely to occur if you are elderly or if you are taking larger doses of the antibiotic.Make sure that your doctor knows all of the medicines that you are taking. Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.

View Reference
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.