Non-Live Vaccines/Efalizumab Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Vaccines cause the body to produce antibodies to protect you against infections. Because efalizumab decreases your body's ability to fight infections, the vaccine may not work.

What might happen:

The vaccine may not work.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking efalizumab before any vaccinations. The vaccination may need to be delayed until your immune system is working better or it may need to be repeated after you are done taking efalizumab.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Raptiva (efalizumab) US prescribing information. Genentech, Inc. March 13, 2009.
  • 2.Kroger A Bahta L Long S Sanchez P. General Best Practice Guideline for Immunization. Best Practices Guidance of the Advisory Committee on Immunzation Practices (ACIP). MMWR. Available at: recs.pdf February 10, 2023;1-197.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.