Allopurinol/Amoxicillin, Ampicillin, Bendamustine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

How this interaction occurs is unknown.

What might happen:

Taking these medicines together may increase your risk of a life-threatening skin condition called Stevens-Johnson syndrome, toxic epidermal necrolysis, or drug reaction with eosinophilia and systemic symptoms.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Stop taking your medicine and call your doctor right away if you develop a peeling skin rash, blisters, or swelling of the mouth/tongue.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 2.Turney R, Skittrall JP, Donovan J, Agranoff D. Drug Reaction, Eosinophilia and Systemic Symptoms (DRESS) syndrome secondary to allopurinol with early lymphadenopathy and symptom relapse. BMJ Case Rep 2015 Oct 5;2015:.
  • 3.Murphy TF. Ampicillin rash and hyperuricemia. Ann Intern Med 1979 Aug; 91(2):324.
  • 4.Excess of ampicillin rashes associated with allopurinol or hyperuricemia. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. N Engl J Med 1972 Mar 9;286(10):505-7.
  • 5.Perez A, Cabrerizo S, de Barrio M, Diaz MP, Herrero T, Tornero P, Baeza ML. Erythema-multiforme-like eruption from amoxycillin and allopurinol. Contact Dermatitis 2001 Feb;44(2):113-4.
  • 6.Sonntag MR, Zoppi M, Fritschy D, Maibach R, Stocker F, Sollberger J, Buchli W, Hess T, Hoigne R. Exanthema during frequent use of antibiotics and antibacterial drugs (penicillin, especially aminopenicillin, cephalosporin and cotrimoxazole) as well as allopurinol. Results of The Berne Comprehensive Hospital Drug Monitoring Program. Schweiz Med Wochenschr 1986 Feb 1;116(5):142-5.
  • 7.Wang F, Ma Z, Wu X, Liu L. Allopurinol-induced toxic epidermal necrolysis featuring almost 60% skin detachment. Medicine (Baltimore) 2019 Jun; 98(25):e16078.
  • 8.Syu FK, Pan HY, Chuang PC, Huang YS, Cheng CY, Cheng FJ. Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. J Dermatol 2018 Sep;45(9):1080-1087.
  • 9.Cheng FJ, Syu FK, Lee KH, Chen FC, Wu CH, Chen CC. Correlation between drug-drug interaction-induced Stevens-Johnson syndrome and related deaths in Taiwan. J Food Drug Anal 2016 Apr;24(2):427-432.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.