Misc Antibiotics/Neuromuscular Blocking Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process your neuromuscular blocking medicine properly.

What might happen:

The effects of the neuromuscular blocking medicine may increase and cause toxic effects.

What you should do about this interaction:

Neuromuscular blockers are only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 2.Emery ERJ. Neuromuscular blocking properties of antibiotics as a cause of post-operative apnoea. Anaesthesia 1963 Jan;18(1):57-65.
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  • 10.Sinha SK, Levene MI. Pancuronium bromide induced joint contractures in the newborn. Arch Dis Child 1984 Jan;59(1):73-5.
  • 11.Burkett L, Bikhazi GB, Thomas KC Jr, Rosenthal DA, Wirta MG, Foldes FF. Mutual potentiation of the neuromuscular effects of antibiotics and relaxants. Anesth Analg 1979 Mar-Apr;58(2):107-15.
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  • 13.Fogdall RP, Miller RD. Prolongation of a pancuronium-induced neuromuscular blockade by clindamycin. Anesthesiology 1974 Oct; 41(4):407-8.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.